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74309d7132 The high polymorphism of the classical MHC loci ensures a diversity in MHC gene expression in the population as a whole. This restricted recognition may sometimes be caused by differences in the conformation of the bound peptide imposed by the different MHC molecules rather than by direct recognition of polymorphic amino acids in the MHC molecule itself. The clearest example of this feature of T-cell recognition came, however, from studies of virus-specific cytotoxic T cells, for which Peter Doherty and Rolf Zinkernagel were awarded the Nobel Prize in 1996.When mice are infected with a virus, they generate cytotoxic T cells that kill self cells infected with the virus, while sparing uninfected cells or cells infected with unrelated viruses. Histocompatibility Antigens Class I at the US National Library of Medicine Medical Subject Headings (MeSH) MHC Class I Genes at the US National Library of Medicine Medical Subject Headings (MeSH) . The organization of the class I, class II, and class III regions of the human MHC are shown, with approximate genetic distances given in thousands of base pairs (kb). It is therefore not surprising that when T cells are tested for their ability to recognize the same peptide bound to different MHC molecules, they readily distinguish the peptide bound to MHCa from the same peptide bound to MHCb.
However, no matter how polymorphic (more.)Thus, with three MHC class I genes and a possible four sets of MHC class II genes on each chromosome 6, a human typically expresses six different MHC class I molecules and eight different MHC class II molecules on his or her cells. 5-15. 5-12. The function of MHC molecules is to bind peptide fragments derived from pathogens and display them on the cell surface for recognition by the appropriate T cells. Thus, the function of the class I MHC is to display intracellular proteins to cytotoxic T cells (CTLs). PMID16917027. Function.